\Un*thread"\, v. t. [1st pref. un- + thread.] 1. To draw or take out a thread from; as, to unthread a needle. 2. To deprive of ligaments; to loose the ligaments of. He with his bare wand can unthread thy joints. --Milton. 3. To make one's way through; to traverse; as, to unthread a devious path. --De Quincey.