\Op"tic*al*ly\, adv. By optics or sight; with reference to optics. {Optically active}, {Optically inactive} (Chem. Physics), terms used of certain metameric substances which, while identical with each other in other respects, differ in this, viz., that they do or do not produce right-handed or left-handed circular polarization of light. {Optically positive}, {Optically negative}. See under {Refraction}.