\Dis`qui*si"tion\, n. [L. disquisitio, fr. disquirere to inquire diligently, investigate; dis- + quaerere to seek. See {Quest}.] A formal or systematic inquiry into, or discussion of, any subject; a full examination or investigation of a matter, with the arguments and facts bearing upon it; elaborate essay; dissertation. For accurate research or grave disquisition he was not well qualified. --Macaulay.