Fewer networkhops away from a backbone or hub. For example, a small ISP that connects to the Internet through a larger ISP that has their own connection to the backbone is downstream from the larger ISP, and the larger ISP is upstream from the smaller ISP.
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Biology Dictionary
Definition:
The region extending in a 5' direction from a gene.
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Glossary
Definition:
The region extending in a 5' direction from a gene.