\Tran`sub*stan`ti*a"tion\, n. [LL. transubstantiatio: cf. F. transsubstantiation.] 1. A change into another substance. 2. (R. C. Theol.) The doctrine held by Roman Catholics, that the bread and wine in the Mass is converted into the body and blood of Christ; -- distinguished from consubstantiation, and impanation.