|   | Definition: |   | A virus in the genus Orthopoxvirus (family Poxviridae) which  causes smallpox, an acute, highly infectious disease that has been all  but eradicated by worldwide vaccination programs. Smallpox, which killed  millions of people in epidemics through the ages, causes vomiting,  chills, fever, and skin eruptions that often cause permanent scars  (pocks). |