1. [adv]  in a significant manner; "our budget will be significantly affected by these new cuts"
2. [adv]  in an important way or to an important degree; "more importantly, Weber held that the manifold meaning attached to the event by the social scientist could alter his definition of the concrete event itself"
3. [adv]  in a statistically significant way; "the two groups differed significantly"

SIGNIFICANTLY is a 13 letter word that starts with S.