| | Definition: | | This is an enzyme from the muscles of the heart, skeletal muscles and the brain. It is released to blood after damage, after which serum level rises in 6 hours, peaks in 18 hours, returns to normal in 2 to 3 days. It is often measured to confirm the clinical diagnosis of myocardial infarction. The isoenzymes can be fractionated by electrophoresis as CPK1 also known as CPK-BB from the brain; CPK 2 also known as CPK-MB originated from myocardial (heart muscle) damage; and CPK3 also known as CPK-MM from the skeletal muscles. CPK is elevated in: - myocardial damage from infarction, defibrillation (cardioversion), and myocarditis
- skeletal muscle damage including convulsion, intramuscular injection, malignant hyperthermia, and radomyolysis
- brain trauma, cardiovascular accidents, electroconvulsive therapy, and tumors
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